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Emergency Medicine Journal 2006;23(5):35862

After viral infection, uncontrolled inflammatory innate responses and compromised adaptive immune responses may cause tissue damage locally as well as systemically [39,40,41]

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247 Using a Smad7 knockout mouse model, a recent study revealed that loss of Smad7 exacerbates TGF--induced fibrosis and inflammation, thereby accelerating salivary gland aging and dysfunction